Dario Calderone studied doublebass with Massimo Giorgi, Franco Petracchi and Stefano Scodanibbio. Between 2001 and 2007 he collaborated as solo doublebass in various orchestras. Since 2007 he has dedicated himself mainly to the diffusion of music composed during the last 40 years. He has collaborated with a number of composers , among others Salvatore Sciarrino, Bernhard Lang, Louis Andriessen, Robert Ashley, Christian Marclay and Yannis Kyriakides, inspiring them in the composition of their works. His activity spaces from solo performances to chamber music, having been regularly invited by the major contemporary musical festivals. He plays with Nieuw Ensemble, NAP, Atlas Ensemble and Ensemble Algoritmo; in 2013 he founded - together with Yannis Kyriakides, Ann La Berge, Wiek Hijmans, Gareth Davis and Reinier Van Hout -  the MAZE ensemble, a group deeply involved in radical experimentations in the field of conceptual composition.
He regularly gives masterclasses at the Tashkent conservatory and at the Amsterdam Conservatory. In 2002 he won the first prize at W. Benzi solo doblebass competition, and in 2006 he won the IMD of Darmstadt's stipendium prize. He recorded a number of CDs for Stradivarius, Attaca records, Wergo and Unsounds. In 2015 he was tutor in the “Impuls Academy” in Graz.